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MYP_058024
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Basic Information
CEME
Anticancer
Anticancer ▸ Anti-proliferative
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
26 amino acids
C136H232N32O30
Standard
Sequence
KWKLFKKIGIGAVLKVLTTGLPALIS
Physicochemical Analysis
2795.49 Da
10.60
4.76
4.54
0.1829
0.84
0.49
0.33
-4.21
150.00
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
988.61
-3.00
35.0
35.0
95.0
198.0
4.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0406511 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin/Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania donovani R9
LD50; MTT assay
PaperThe plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide PMID9461543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9461543/
RECORD: Rec_0413630 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium vaccae strain (ATCC 15483)
1.0 μM
MIC
PMID23716047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23716047/
RECORD: Rec_0419382 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa H374
2 μg/mL
MIC
PMID10085049 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10085049/
RECORD: Rec_0421176 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://patents.google.com/patent/US20030176337A1/en PatentUS 2003/0176337 A1
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