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MYP_058024
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Basic Information
CEME
Anticancer
Anticancer ▸ Anti-proliferative
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
26 amino acids
C136H232N32O30
Standard
Sequence
KWKLFKKIGIGAVLKVLTTGLPALIS
Physicochemical Analysis
2795.49 Da
10.60
4.76
4.54
0.1829
0.84
0.49
0.33
-4.21
150.00
0.0769
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
988.61
-3.00
35.0
35.0
95.0
198.0
4.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0181813 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa K799
5 μg/mL
MIC
PMID10085049 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10085049/
RECORD: Rec_0197761 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin/Melittin hybrid
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania donovani R9
2.9 μM
MTT assay
PaperThe plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide PMID9461543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9461543/
RECORD: Rec_0201586 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer Anti-proliferative
PaperPatent US 6906035 B2 Evidence URLhttps://patents.google.com/patent/US6906035B2/en PatentUS 6906035 B2
RECORD: Rec_0202819 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa Z61
4 μg/mL
MIC
PMID10085049 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10085049/
RECORD: Rec_0211816 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium
2 μg/mL
MIC
PMID10085049 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10085049/
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