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MYP_058022
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Basic Information
AR-23 [A1,8R;I17R]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C117H205N39O28
Standard
Sequence
RIGSILGRLAKGLPTLRSWIKNR
Physicochemical Analysis
2606.12 Da
12.00
5.76
5.55
0.2504
-0.21
0.79
-0.13
46.41
123.04
0.0435
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1113.94
-9.92
42.0
34.0
89.0
184.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010504 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
10 % hemolysis at 100 μM
Hemolysis
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0028066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis CGMCC 1.3376
12.5 μM
MIC
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0035735 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
3.13 μM
MIC
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0117693 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus CGMCC 1.8721
100 μM
MIC
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0124750 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
In L929 cells, the cell viability is 92%, 92%, 80%, 60% and 12% at peptide concentrations of 3
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
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