Peptide Database

Peptide NameDermaseptin S4 (1-24)a

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC120H210N30O27S

DescriptionStandard

        ALWMTLLKKVLKAAAKAALNAVLV
    

Molecular Weight2537.20 Da

Isoelectric Point (pI)10.48

Net Charge (pH 7.0)3.79

Net Charge (pH 7.4) 3.60

Charge Density (pH 7.0) 0.1580

GRAVY Index1.22

Hydrophobic Moment 0.71

Boman Index0.36

Instability Index17.50

Aliphatic Index 162.92

Aromaticity 0.0417

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 915.81

LogP -2.82

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 86.0

Heavy Atoms 178.0

Ring Count 2.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0397071 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDermaseptin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsE. coli Urine DS, S2 = E. coli Urine MDR, S3 = K. pneumoniae Urine DS, S4 = C. striatum Wound exudate MDR, S5 = C. striatum Wound exudate MDR, S6 = C. striatum Wound exudate MDR, S7 = C. striatum Wound exudate MDR (DS = drug sensitive, MDR = multi drug resistant), C-terminal: CONH2

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetS2

Activity331.5 μg/mL

MethodMIC

RECORD: Rec_0405920 VERIFIED: YES