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MYP_057981
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Basic Information
Dermaseptin S4 (1-24)a
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C120H210N30O27S
Standard
Sequence
ALWMTLLKKVLKAAAKAALNAVLV
Physicochemical Analysis
2537.20 Da
10.48
3.79
3.60
0.1580
1.22
0.71
0.36
17.50
162.92
0.0417
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
915.81
-2.82
32.0
32.0
86.0
178.0
2.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008483 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: SW620 (71.48±4.81% Cytotoxicity=256 μg/ml)
PMID33774792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33774792/
RECORD: Rec_0016682 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
E. coli Urine DS, S2 = E. coli Urine MDR, S3 = K. pneumoniae Urine DS, S4 = C. striatum Wound exudate MDR, S5 = C. striatum Wound exudate MDR, S6 = C. striatum Wound exudate MDR, S7 = C. striatum Wound exudate MDR (DS = drug sensitive, MDR = multi drug resistant), C-terminal: CONH2
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S5
269.04 μg/mL
MIC
PMID33774792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33774792/
RECORD: Rec_0046313 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: 57
PMID33774792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33774792/
RECORD: Rec_0089040 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
E. coli Urine DS, S2 = E. coli Urine MDR, S3 = K. pneumoniae Urine DS, S4 = C. striatum Wound exudate MDR, S5 = C. striatum Wound exudate MDR, S6 = C. striatum Wound exudate MDR, S7 = C. striatum Wound exudate MDR (DS = drug sensitive, MDR = multi drug resistant), C-terminal: CONH2
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S7
264.3 μg/mL
MIC
PMID33774792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33774792/
RECORD: Rec_0134880 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
E. coli Urine DS, S2 = E. coli Urine MDR, S3 = K. pneumoniae Urine DS, S4 = C. striatum Wound exudate MDR, S5 = C. striatum Wound exudate MDR, S6 = C. striatum Wound exudate MDR, S7 = C. striatum Wound exudate MDR (DS = drug sensitive, MDR = multi drug resistant), C-terminal: CONH2
Bio-Activity Profile
Hemolytic
human RBCs
128 μg/mL
Hemolysis
PMID33774792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33774792/
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