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MYP_057979
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Basic Information
Lantibiotic mutacin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
27 amino acids
C147H210N42O39S4
Standard
Sequence
NRWWQGVVPTVSYECRMNSWQHVFTCC
Physicochemical Analysis
3317.76 Da
7.97
0.82
0.52
0.0303
-0.36
0.55
0.01
51.46
42.96
0.1852
17990.00
18115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1321.79
-11.94
50.0
45.0
99.0
232.0
10.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0247804 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0267195 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
H.pylori
PMID8592997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8592997/
RECORD: Rec_0281612 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Neisseria gonorrhoeae
PaperPubMed PMID: 10821848 | PubMed PMID: 8592997 | PubMed PMID: 16626493 | PubMed PMID: 8021218 PMID10821848;8592997;16626493;8021218 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10821848/
RECORD: Rec_0286025 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperMutacin H-29B is identical to mutacin II (J-T8).
RECORD: Rec_0286493 VERIFIED: YES
Provenance & Taxonomy
Streptococcus mutans [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
P.acidilactici
PMID8592997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8592997/
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