Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2338H3770N600O666S18

DescriptionStandard

        MLLRCWLALLVALIPAALSTNPGVKVKLTEKGIEYGKLLGMAALQTRLKSIKVPDISGSQSVSPIGKVQYSLTNMQITNIGLPKSEVDLVPGSAVKLSIGDAYISLNGHWRVKYLRFIKDSGSFDLNVNGLTITTGIAIKSDETGRPAVSSVNCAATVGSAKIKFHGGASWLYNLFEKFVDKALRNALQKQICPLVADAVSDLNPHLKTLNVLAKVDQYAEIEYSMVSSPIISNSSIDLSLKGEFYNIGRHQEPPFSPKDFSLPPQINNMLYIGMSVFTANSAAFVYDKAGALSLYITDDMIPKGSPFRLNTRTFGVFIPQIAQKFPGLMMKLLVKTVKNPIITFEPNNVTIQATATVTAYAIQPNSTLSPLFVLNLETSVSANVFVSGMRLAGSVTLNKMNLTLGTSYVGQFQVRSLDNMLQMLLKVVVIPKLNVQLGKGYPLPTIGKMKLVNSQLQVLKDYMLIGTDVQFTG
    

Molecular Weight51517.73 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)15.82

Net Charge (pH 7.4) 15.26

Charge Density (pH 7.0) 0.0334

GRAVY Index0.20

Hydrophobic Moment 0.81

Boman Index0.16

Instability Index31.18

Aliphatic Index 106.71

Aromaticity 0.0781

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 38975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0343379 VERIFIED: NO

Provenance & Taxonomy

OrganismAmphiprion ocellaris [Bacterium]

FamilyBPI

Tax ID80972

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence