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MYP_057912
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Basic Information
Cathelicidin-RC1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C159H264N38O32S2
Standard
Sequence
KKCKFFCKVKKKIKSIGFQIPIVSIPFK
Physicochemical Analysis
3284.16 Da
10.32
8.73
8.49
0.3118
0.12
0.68
0.01
-4.06
90.36
0.1429
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1149.17
-4.08
41.0
43.0
116.0
231.0
6.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0331287 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0333771 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeiana [Animal]
cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Proteus mirabilis
18.75 μg/mL
MIC
PMID24675879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24675879/
RECORD: Rec_0357704 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-7
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
2.8-5.7 μM
MIC
PaperCathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design
RECORD: Rec_0368054 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-7
Bio-Activity Profile
Antimicrobial Antifungal
P. mirabilis
5.7 μM
MIC
PaperCathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design
RECORD: Rec_0372258 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeiana [Animal]
cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus 4
200 μg/mL
MIC
PMID24675879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24675879/
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