Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length184 amino acids

Chemical FormulaC927H1486N258O247S10

DescriptionStandard

        PKTPPMAHEPMLLLAVTELIANSAAFTYFTAGAMRRNISSDMLPRRFPLQLRTKSMEVFCPQLQERYPDQPMELHLWARRQPLLSCHPDALHGSLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLVPDPELGLPVPQVKRLETLLKFALWLFGVPRANSKCCPRLVP
    

Molecular Weight20517.95 Da

Isoelectric Point (pI)9.87

Net Charge (pH 7.0)8.29

Net Charge (pH 7.4) 7.94

Charge Density (pH 7.0) 0.0450

GRAVY Index-0.01

Hydrophobic Moment 0.57

Boman Index0.06

Instability Index55.46

Aliphatic Index 95.43

Aromaticity 0.0707

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7940.11

LogP -89.52

H-bond Donors 275.0

H-bond Acceptors 269.0

Rotatable Bonds 650.0

Heavy Atoms 1442.0

Ring Count 40.0

Amide Bonds 196.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0288005 VERIFIED: NO

Provenance & Taxonomy

OrganismCnemophilus loriae [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria