Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length514 amino acids

Chemical FormulaC2643H4089N651O743S21

DescriptionStandard

        MCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGMEMIEQMVKERNIQDLKGSESPEFLKIYYVNYHFINIKINAFALPNTSLAFVPGVGIRALINHGTANISTDWEIKSPLFQDTGGADLFLSGVYFTGIVVLAQDDFGHPILKLQDCYAQVSHNDISFSGELSVLYNSFAEPMEKPILKNLNKMLCPIITSEVEAVNANLSRLEVLRKIDNYTLLDYSLISSPEITENYIDLNLKGVFYPLENLTDPPFSSVPFVLPEHNDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTEEIFSHLIRNSQGLGNMLSRIAELYILSQPFMVQVLATQPPVVNLLPGNFTLDIPASFVILTQSKNSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFHLSLPESSRSNVEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFVNSDIEVLEVRIININCPISFHSRICLFLFCLLFVLFCFALFFPSPGNFINKMFSS
    

Molecular Weight57545.02 Da

Isoelectric Point (pI)5.42

Net Charge (pH 7.0)-10.66

Net Charge (pH 7.4) -11.62

Charge Density (pH 7.0) -0.0207

GRAVY Index0.30

Hydrophobic Moment 0.69

Boman Index0.21

Instability Index46.63

Aliphatic Index 107.92

Aromaticity 0.1148

Extinction Coeff. Reduced 43320.00

Extinction Coeff. Oxidized 43820.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0363057 VERIFIED: NO

Provenance & Taxonomy

OrganismPhyseter macrocephalus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria