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MYP_057809
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Basic Information
Haloduracin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
28 amino acids
C139H217N41O43S5
Standard
Sequence
CEWYNISCQLGNKGQWCTLTKECQRSCK
Physicochemical Analysis
3310.78 Da
8.40
1.71
1.43
0.0612
-0.82
0.60
-0.19
83.29
41.79
0.1071
12490.00
12740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1411.76
-16.39
54.0
50.0
111.0
228.0
5.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025509 VERIFIED: YES
Provenance & Taxonomy
Bacillus licheniformis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0030235 VERIFIED: YES
Provenance & Taxonomy
Bacillus paralicheniformis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
disulfide bond between C1-C8, lanthionine bridges between S7-C17, T18-C23, and T20-C27; Chain B: lanthionine bridges between T1-C8, T13-C17, S19-C23, T23-C26). In addition, T2, S4, S5, and T10 are dehydrated into Dha or Dhb. Formicin is unique as the chain A is much less hydrophobic but most positively charged than other similar chains; chain B contains a negative charge (sequence: TTPSSLPCGTLVTAVWCPSNACTSDC)
Bio-Activity Profile
Antimicrobial
(e.g., L. delbrueckii subsp. bulgaricus; L. amylophilus; L. lactis; Micrococcus luteus; S. smutans), including clinical strains Staphylococcus aureus, C. difficile
PaperFormicin - a novel broad-spectrum two-component lantibiotic produced by Bacillus paralicheniformis APC 1576.
RECORD: Rec_0043454 VERIFIED: YES
Provenance & Taxonomy
Bacillus paralicheniformis [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
including clinical strains S
PaperPubMed PMID: 27450592 PMID27450592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27450592/
RECORD: Rec_0061275 VERIFIED: YES
Provenance & Taxonomy
Bacillus paralicheniformis [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
luteus
PaperPubMed PMID: 27450592 PMID27450592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27450592/
RECORD: Rec_0099027 VERIFIED: YES
Provenance & Taxonomy
Bacillus paralicheniformis [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PaperPubMed PMID: 27450592 PMID27450592 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27450592/
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