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MYP_057706
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Basic Information
Merecidin (17BIPHE2-R23O)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
17 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GXKRLVQXLKDXLRNLV
Physicochemical Analysis
0.00 Da
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0031230 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; ornithine at 8; biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
3.1 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0054305 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; ornithine at 8; biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Hemolytic
Human RBC
300 μM
Hemolysis
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0186790 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; ornithine at 8; biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus USA300
3.1 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0234187 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; ornithine at 8; biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO1
6.2 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0300374 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; ornithine at 8; biphenylalanine, O= L-ornithine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
12.5 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/