Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length461 amino acids

Chemical FormulaC2329H3600N582O655S23

DescriptionStandard

        MHKYQHASFWMCYVCLLCVCAVTHWLTDWLQNELGNITLPAVKGSVFIIFGSVEYVLYNMSIQRCDLPEPSVAFSEGTGMSLQVSGLSIAITGLWNTRYGIIKDGGWFELVMFTVSLNTVLQLGREDGRLSISTPVCSADVESVQMNFHGGGSPIFQPFVKFFHKHITSEIRAKICQTFVKEIEALESHLAAMSVALKVDSYVYMNISLTDSPLVKDSGLGLNVKGEFYSNNFPSEPPFPSNHFELSWREDYMVSLGASEFFVNSAAYAYQRAGALKIRITDDMIPKASPFHLNTSQFGQLIPQLPKKYPDLPMQILLYASDAPLFSFNKTVINVNVSASAKAYAMKANSVAIPLFRLDVESSFSGKAYIDKYLLKGVLQMKNLTVTLGATEIGCFPVGPIEQALKLIMSSFVLPKLNAQLKDGLPLPRVKGFGLRNSVMTIENGFLALATDLSAPYGSWQ
    

Molecular Weight50970.50 Da

Isoelectric Point (pI)6.75

Net Charge (pH 7.0)-0.76

Net Charge (pH 7.4) -1.66

Charge Density (pH 7.0) -0.0017

GRAVY Index0.17

Hydrophobic Moment 0.70

Boman Index0.18

Instability Index46.60

Aliphatic Index 95.16

Aromaticity 0.1128

Extinction Coeff. Reduced 63830.00

Extinction Coeff. Oxidized 64330.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340301 VERIFIED: NO

Provenance & Taxonomy

OrganismPygocentrus nattereri [Bacterium]

FamilyBPI

Tax ID42514

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence