Peptide Database

Peptide NameCholecystokinin-18

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC94H133N27O30S2

DescriptionStandard

        DPSHRISDRDYMGWMDFG
    

Molecular Weight2185.35 Da

Isoelectric Point (pI)4.56

Net Charge (pH 7.0)-2.15

Net Charge (pH 7.4) -2.41

Charge Density (pH 7.0) -0.1194

GRAVY Index-1.18

Hydrophobic Moment 0.44

Boman Index-0.19

Instability Index56.19

Aliphatic Index 21.67

Aromaticity 0.1667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 927.39

LogP -8.75

H-bond Donors 33.0

H-bond Acceptors 31.0

Rotatable Bonds 68.0

Heavy Atoms 153.0

Ring Count 6.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0145353 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCholecystokinin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods11:Sulfotyrosine; 17:Phenylalanine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour

RECORD: Rec_0172953 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCholecystokinin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods11:Sulfotyrosine; 17:Phenylalanine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

Half-LifeMammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour

RECORD: Rec_0392040 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyGastrin/cholecystokinin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsTyr11 Sulfotyrosine; Phe17 Amidation

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide