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MYP_057559
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Basic Information
Phylloseptin-L1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C84H151N19O22S
Standard
Sequence
LLGMIPLAISAISALSKL
Physicochemical Analysis
1811.28 Da
8.75
0.76
0.55
0.0422
1.75
0.40
0.58
3.13
190.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
635.94
-2.94
22.0
24.0
60.0
126.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0192513 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Toxic Antimicrobial Antifungal Hemolytic Anti-Gram-positive Cytotoxic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0194616 VERIFIED: YES
Provenance & Taxonomy
Agalychnis lemur [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Gram-negative Anti-Gram-positive Cytolytic Anticancer Hemolytic
Staphylococcus aureus
PMID17561225;18644413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17561225/
RECORD: Rec_0198477 VERIFIED: YES
Provenance & Taxonomy
Hylomantis lemur [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
erythrocytes
40 μM
LC50
PaperPeptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae).
RECORD: Rec_0200399 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Horse erythrocytes
32000 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/23415652/ PMID23415652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415652/
RECORD: Rec_0210825 VERIFIED: YES
Provenance & Taxonomy
Hylomantis lemur [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Hemolytic 80% at 128 ug/mL
~70 μg/mL
HC50
PaperPeptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae).
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