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MYP_057559
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Basic Information
Phylloseptin-L1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C84H151N19O22S
Standard
Sequence
LLGMIPLAISAISALSKL
Physicochemical Analysis
1811.28 Da
8.75
0.76
0.55
0.0422
1.75
0.40
0.58
3.13
190.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
635.94
-2.94
22.0
24.0
60.0
126.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0099809 VERIFIED: YES
Provenance & Taxonomy
Hylomantis lemur,Agalychnis callidryas [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human HepG2 cells
35 μM
LC50
PMID17561225 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17561225/
RECORD: Rec_0152052 VERIFIED: YES
Provenance & Taxonomy
skin secretions of the lemur leaf frog Hylomantis lemur [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Hep-G2
35 μM
LC50
PaperPubMed PMID: 17561225 PMID17561225 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17561225/
RECORD: Rec_0170119 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
40 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/17561225/ PMID17561225 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17561225/
RECORD: Rec_0184557 VERIFIED: YES
Provenance & Taxonomy
Hylomantis lemur [Animal]
Hylomantis lemur (Hylidae: Phyllomedusinae
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
Colorectal Cancer (Not Available)
PMID17561225;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17561225/
RECORD: Rec_0190449 VERIFIED: NO
Provenance & Taxonomy
Agalychnis lemur [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID17561225;18644413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17561225/
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