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MYP_057559
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Basic Information
Phylloseptin-L1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C84H151N19O22S
Standard
Sequence
LLGMIPLAISAISALSKL
Physicochemical Analysis
1811.28 Da
8.75
0.76
0.55
0.0422
1.75
0.40
0.58
3.13
190.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
635.94
-2.94
22.0
24.0
60.0
126.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016112 VERIFIED: NO
Provenance & Taxonomy
Amphibia [Animal]
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0020567 VERIFIED: YES
Provenance & Taxonomy
Agalychnis lemur [Animal]
Phylloseptin
317382
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
8.0 μM
MIC
PaperJ.M. Conlon et al. / Toxicon 50 (2007) 498-506. Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae) PMID17561225 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17561225/
RECORD: Rec_0052322 VERIFIED: YES
Provenance & Taxonomy
Hylomantis lemur [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Candida albicans
32 μg/mL
MIC
PaperPeptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae).
RECORD: Rec_0053555 VERIFIED: YES
Provenance & Taxonomy
Agalychnis lemur [Animal]
Phylloseptin-like
317382
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C-terminal amide reported in literature sequence
Bio-Activity Profile
Anticancer
HepG2
35 μM
LC50
PaperPeptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae) PMID17561225;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17561225/
RECORD: Rec_0057965 VERIFIED: YES
Provenance & Taxonomy
Hylomantis lemur [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Cytolytic Hemolytic Cytotoxic Anticancer
HepG2
35 μM
LC50
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