Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length80 amino acids

Chemical FormulaC389H645N99O112S3

DescriptionStandard

        MYPDMLMKLQISSTSAPLLDIKPGNLTISPKLDIQAYVILPNSSLAPAFLLNLTTTALAKVAVNSGRIVGSLQLSRYVHT
    

Molecular Weight8597.07 Da

Isoelectric Point (pI)9.60

Net Charge (pH 7.0)2.58

Net Charge (pH 7.4) 2.31

Charge Density (pH 7.0) 0.0323

GRAVY Index0.42

Hydrophobic Moment 0.53

Boman Index0.21

Instability Index36.08

Aliphatic Index 124.38

Aromaticity 0.0500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3343.71

LogP -30.74

H-bond Donors 114.0

H-bond Acceptors 119.0

Rotatable Bonds 279.0

Heavy Atoms 603.0

Ring Count 11.0

Amide Bonds 86.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0042215 VERIFIED: NO

Provenance & Taxonomy

OrganismEleutherodactylus coqui [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence