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MYP_057467
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Basic Information
Ranatuerin-2SEc
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
28 amino acids
C127H228N34O38S3
Standard
Sequence
GIMDTIKDTAKTVAVGLLNKLKCKITGC
Physicochemical Analysis
2935.57 Da
9.24
2.74
2.50
0.0978
0.35
0.61
0.11
-13.86
111.43
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1177.73
-11.38
43.0
44.0
104.0
202.0
0.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010339 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-28
Bio-Activity Profile
Antimicrobial Antibacterial Mast cell degranulation Histamine releasing
PaperC. Graham et al. / Peptides 27 (2006) 1313-1319. Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa Evidence URLhttps://www.uniprot.org/uniprotkb/P85053/entry
RECORD: Rec_0073269 VERIFIED: YES
Provenance & Taxonomy
Dusky gopher [Animal]
Ranatuerin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-28
Bio-Activity Profile
Antimicrobial
PMID17764786 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17764786/
RECORD: Rec_0095053 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0156062 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Frog skin active peptide (FSAP); Ranatuerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Non-hemolytic
Escherichia coli (Gram-negative)
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0170039 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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