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MYP_057419
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Basic Information
Peptide5
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
15 amino acids
C79H120N18O27
Standard
Sequence
IYALLENAEDYNLVN
Physicochemical Analysis
1753.90 Da
4.05
-3.24
-3.44
-0.2157
0.01
0.42
0.18
37.96
136.67
0.1333
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
752.35
-5.21
24.0
24.0
56.0
124.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0250483 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/
RECORD: Rec_0326192 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 | HEK293T/ACE2 cells
0.009±0.004 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperSynthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein | Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR. | J Med Chem. 2022 Feb 24;65(4):2836-2847. | DOI:10.1021/acs.jmedchem.1c00477 | PMID:34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/
RECORD: Rec_0365309 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV-2:Inhibition of virus entry in HEK293T/ACE2 cells (via inhibition of SRBD:ACE2 interaction)
9±4 μM
IC50
PaperPubMed PMID: 34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/