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MYP_057340
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Basic Information
PC3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C84H141N33O20S4
Standard
Sequence
RGGGLCYCRRRFCVCVGR
Physicochemical Analysis
2061.49 Da
9.88
4.72
4.46
0.2622
-0.02
0.39
-0.27
68.99
53.89
0.1111
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
887.75
-10.25
39.0
29.0
67.0
141.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0047970 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
80 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/18455267/ PMID18455267 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18455267/
RECORD: Rec_0076023 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0096960 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans strain 820
PaperPubMed PMID: 8335113 PMID8335113 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8335113/
RECORD: Rec_0100197 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Defensin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Candida albicans (Cho Y et al., 1998). Chemical modification: Two disulfide bridges:6,15; 8,13; Structure: You can rotate, zoom
PaperProtegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins.
RECORD: Rec_0103510 VERIFIED: NO
Provenance & Taxonomy
Sus scrofa [Animal]
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
E. coli, C. albicans, Listeria monocytogenes
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