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MYP_057334
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Basic Information
Murepavadin [T1L,W2S,I3Y,DAB10tBuGly]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
14 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LSYXXXXWXXASPP
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0195586 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 4,5,6,7,9,10
Bio-Activity Profile
Hemolytic
Human erythrocytes
7 % Hemolysis
Hemolysis
PMID31645764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31645764/
RECORD: Rec_0217672 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 4,5,6,7,9,10
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 29213
64 μg/mL
MIC
PMID31645764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31645764/
RECORD: Rec_0225284 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 4,5,6,7,9,10
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 27853
4 μg/mL
MIC
PMID31645764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31645764/
RECORD: Rec_0231757 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID31645764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31645764/
RECORD: Rec_0253772 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
unspecified non-canonical residue at 4,5,6,7,9,10
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
0.5 μg/mL
MIC50
PMID31645764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31645764/
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