Peptide Database

Peptide NameSLAY-screened peptide P3776

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC117H165N23O29

DescriptionStandard

        LVPSDPVPPYPYYQPLHLVY
    

Molecular Weight2357.70 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.42

Charge Density (pH 7.0) -0.0578

GRAVY Index-0.09

Hydrophobic Moment 0.23

Boman Index0.29

Instability Index75.85

Aliphatic Index 102.00

Aromaticity 0.2000

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 773.70

LogP -0.76

H-bond Donors 23.0

H-bond Acceptors 29.0

Rotatable Bonds 58.0

Heavy Atoms 169.0

Ring Count 11.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0150853 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/