Peptide Database

Peptide NameSLAY-screened peptide P381

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC70H97N17O15S

DescriptionStandard

        WFAPCKSAAIHAF
    

Molecular Weight1448.69 Da

Isoelectric Point (pI)8.23

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.57

Charge Density (pH 7.0) 0.0643

GRAVY Index0.72

Hydrophobic Moment 0.12

Boman Index0.41

Instability Index27.74

Aliphatic Index 60.77

Aromaticity 0.2308

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 494.45

LogP -1.93

H-bond Donors 18.0

H-bond Acceptors 18.0

Rotatable Bonds 40.0

Heavy Atoms 103.0

Ring Count 6.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0216488 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/