Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length106 amino acids

Chemical FormulaC502H814N148O147S10

DescriptionStandard

        MKLLLLVFASFGFLVTPASGGGTSCGRKYPGRCKLHCHSQERSIFICDRYRLCCMKNPIEGITASPVHRAKHPCRKTTESQNVEQQMASTPQPLSSPSIPSTVISS
    

Molecular Weight11595.39 Da

Isoelectric Point (pI)9.46

Net Charge (pH 7.0)7.78

Net Charge (pH 7.4) 7.24

Charge Density (pH 7.0) 0.0734

GRAVY Index-0.22

Hydrophobic Moment 0.54

Boman Index-0.02

Instability Index60.89

Aliphatic Index 69.91

Aromaticity 0.0566

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4697.27

LogP -56.01

H-bond Donors 171.0

H-bond Acceptors 169.0

Rotatable Bonds 377.0

Heavy Atoms 807.0

Ring Count 19.0

Amide Bonds 112.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0010594 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyDefensin

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KS2/entry; https://bblserver.org.in/ampdb/

RECORD: Rec_0287842 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-stabilized linear peptide scaffold [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin

RECORD: Rec_0313889 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus dingo [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-stabilized linear peptide scaffold [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin