Peptide Database

Peptide NameAvelumab

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immuno-oncology

Standard StatusStandard

Sequence Length450 amino acids

Chemical FormulaC2194H3418N578O670S16

DescriptionStandard

        EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYIMMWVRQAPGKGLEWVSSIYPSGGITFYADTVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARIKLGTVTTVDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
    

Molecular Weight49125.12 Da

Isoelectric Point (pI)8.60

Net Charge (pH 7.0)6.54

Net Charge (pH 7.4) 5.63

Charge Density (pH 7.0) 0.0145

GRAVY Index-0.31

Hydrophobic Moment 0.50

Boman Index0.04

Instability Index42.55

Aliphatic Index 74.18

Aromaticity 0.0911

Extinction Coeff. Reduced 72310.00

Extinction Coeff. Oxidized 72935.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0245248 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Mus musculus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10090

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Immuno-oncology

Half-LifeThe terminal half-life is approximately 6.1 days in patients receiving 10 mg/kg.