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MYP_057017
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Basic Information
THP-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
40 amino acids
C190H320N58O51S6
Standard
Sequence
GKREKCLRRNGFCAFLKCPTLSVISGTCSRFQVCCKTLLG
Physicochemical Analysis
4425.32 Da
9.61
6.70
6.40
0.1675
0.13
0.46
-0.06
42.55
75.50
0.0750
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1785.97
-20.05
71.0
64.0
150.0
305.0
4.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0175787 VERIFIED: YES
Provenance & Taxonomy
Meleagris gallopavo [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bonds
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
8 μg/mL
MIC
PaperIsolation of antimicrobial peptides from avian heterophils.
RECORD: Rec_0186490 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0245858 VERIFIED: YES
Provenance & Taxonomy
Meleagris gallopavo [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bonds
Bio-Activity Profile
Antimicrobial Antifungal
S. typhimurium
4 μg/mL
MIC
PaperIsolation of antimicrobial peptides from avian heterophils.
RECORD: Rec_0276749 VERIFIED: YES
Provenance & Taxonomy
Meleagris gallopavo [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0304332 VERIFIED: YES
Provenance & Taxonomy
Meleagris gallopavo [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bonds
Bio-Activity Profile
Antimicrobial Antifungal
C. jejuni
2 μg/mL
MIC
PaperIsolation of antimicrobial peptides from avian heterophils.
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