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MYP_057010
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Basic Information
Hexarelin
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-wrinkle
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Collagen boosting
Standard
6 amino acids
C46H55N11O7
Standard
Sequence
HWAWFK
Physicochemical Analysis
874.00 Da
8.76
0.85
0.59
0.1411
-0.72
0.23
0.26
-46.57
16.67
0.5000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
295.10
1.63
11.0
9.0
23.0
64.0
6.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0056047 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Hexarelin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
-
Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Hexarelin (Rattus norvegicus): PMID 7910650 PMID7910650 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7910650/
RECORD: Rec_0109635 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GHRH/CRF
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Trp methylated at position 2
Bio-Activity Profile
Endocrine
ED50
Twelve adult male volunteers, in vivo; 3000 s
PMID7957536 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7957536/
RECORD: Rec_0110674 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Growth hormone secretagogue-derived peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Biotinylation
Bio-Activity Profile
Anti-aging Anti-wrinkle Collagen boosting
Human neonatal primary dermal fibroblast (hDFn) (In vitro)
Immunostaining; Histology
PaperAnti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression PMID31861912 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31861912/
RECORD: Rec_0291296 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
GHRH/CRF
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Methylated at position 2 of D-trp
Bio-Activity Profile
Endocrine
Radioimmunoassay
Subcutaneous injection to male and female dogs, in vivo; 1500 s
PMID8545255 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8545255/
RECORD: Rec_0298568 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
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