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MYP_056978
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Basic Information
Pardaxin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
33 amino acids
C154H248N36O45
Standard
Sequence
GFFALIPKIISSPLFKTLLSAVGSALSSSGGQE
Physicochemical Analysis
3323.83 Da
8.59
0.77
0.56
0.0232
0.75
0.50
0.37
39.52
112.42
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1271.21
-13.02
44.0
46.0
108.0
235.0
5.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0318765 VERIFIED: YES
Provenance & Taxonomy
Sea moses sole [Animal]
Pardaxin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Escherichia coli, A. calcoaceticus, Pseudomonas aeruginosa (25 uM), S. typhirnuriunz (40 uM), B. rnegateriurn, Micrococcus luteus
PaperSequencing and synthesis of pardaxin, a polypeptide from the Red Sea Moses sole with ionophore activity
RECORD: Rec_0326521 VERIFIED: YES
Provenance & Taxonomy
Pardachirus marmoratus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
Micrococcus luteus(MIC=100 mg/L)
PaperPubMed PMID: 12124282 | PubMed PMID: 19959835 | PubMed PMID: 15292173 | PubMed PMID: 23598079 PMID12124282;19959835;15292173;23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12124282/
RECORD: Rec_0329964 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
[NH(CH 2 ) 2 NH 2 ] 2
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
12 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/8620888/ PMID8620888 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8620888/
RECORD: Rec_0333950 VERIFIED: YES
Provenance & Taxonomy
Pardachirus marmoratus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
Grouper Vibrio alginolyticus(MIC=50 mg/L)
PaperPubMed PMID: 12124282 | PubMed PMID: 19959835 | PubMed PMID: 15292173 | PubMed PMID: 23598079 PMID12124282;19959835;15292173;23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12124282/
RECORD: Rec_0342579 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
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