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MYP_056978
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Basic Information
Pardaxin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
33 amino acids
C154H248N36O45
Standard
Sequence
GFFALIPKIISSPLFKTLLSAVGSALSSSGGQE
Physicochemical Analysis
3323.83 Da
8.59
0.77
0.56
0.0232
0.75
0.50
0.37
39.52
112.42
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1271.21
-13.02
44.0
46.0
108.0
235.0
5.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0234305 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0238361 VERIFIED: YES
Provenance & Taxonomy
Pardachirus marmoratus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
PaperPubMed PMID: 12124282 | PubMed PMID: 19959835 | PubMed PMID: 15292173 | PubMed PMID: 23598079 PMID12124282;19959835;15292173;23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12124282/
RECORD: Rec_0248006 VERIFIED: YES
Provenance & Taxonomy
Pardachirus marmoratus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
Vibrio vulnificus(MIC=100 mg/L)
PaperPubMed PMID: 12124282 | PubMed PMID: 19959835 | PubMed PMID: 15292173 | PubMed PMID: 23598079 PMID12124282;19959835;15292173;23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12124282/
RECORD: Rec_0265681 VERIFIED: YES
Provenance & Taxonomy
Epinephelus nebulosus [Animal]
Epinephelus nebulosus
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
HeLa
6.25 μg/mL
Cytotoxicity assay
PaperTruncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus PMID23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23598079/
RECORD: Rec_0266778 VERIFIED: YES
Provenance & Taxonomy
Pardachirus marmoratus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic Hemolytic
PaperPubMed PMID: 12124282 | PubMed PMID: 19959835 | PubMed PMID: 15292173 | PubMed PMID: 23598079 PMID12124282;19959835;15292173;23598079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12124282/
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