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MYP_056961
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Basic Information
Unnamed
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
50 amino acids
C242H382N76O76S5
Standard
Sequence
YRQSMNQGSRSTGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGY
Physicochemical Analysis
5732.41 Da
9.70
4.82
4.53
0.0965
-1.15
0.60
-0.27
44.77
27.40
0.1000
4470.00
4595.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2531.15
-33.25
90.0
87.0
194.0
399.0
8.0
57.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0328094 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Rattus norvegicus [Animal]
9606;10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hypotensive
Competitive Radioimmunoassay
Intravenous administration in Rat, in vivo; 120 s
PMID15740458 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15740458/
RECORD: Rec_0350902 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]
Adrenomedullin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Neuropeptide Hormone Vasoregulatory peptide
Evidence URLhttps://www.uniprot.org/uniprotkb/ADML_RAT/entry
RECORD: Rec_0382379 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Adrenomedullin
10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
14-19
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Vasoconstrictor Cardiovascular Reproductive regulator Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
Experimental: 1.05±0.04 minutes; /63 seconds; Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Adrenomedullin (Rattus norvegicus): PMID 8542672 PMID8542672 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8542672/
RECORD: Rec_0406492 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Rattus norvegicus [Animal]
Calcitonin family
9606; 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
14-19
Bio-Activity Profile
Hypotensive Vasodilatory
Rat after intravenous administration (elimination phase)
Competitive radioimmunoassay
15.9 min
PaperBiodistribution, plasma kinetics and quantification of single-pass pulmonary clearance of adrenomedullin
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