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MYP_056961
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Basic Information
Unnamed
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
50 amino acids
C242H382N76O76S5
Standard
Sequence
YRQSMNQGSRSTGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGY
Physicochemical Analysis
5732.41 Da
9.70
4.82
4.53
0.0965
-1.15
0.60
-0.27
44.77
27.40
0.1000
4470.00
4595.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2531.15
-33.25
90.0
87.0
194.0
399.0
8.0
57.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0124749 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Rattus norvegicus [Animal]
Calcitonin family
9606; 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
14-19
Bio-Activity Profile
Hypotensive Vasodilatory
Wistar-Kyoto rat plasma (slow component)
Radioimmunoassay
16.3 ± 1.2 min
PaperSynthetic human adrenomedullin and adrenomedullin 15-52 have potent short-lived vasodilator activity in the hindlimb vascular bed of the cat
RECORD: Rec_0286283 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Rattus norvegicus [Animal]
Calcitonin family
9606; 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
14-19
Bio-Activity Profile
Hypotensive Vasodilatory
Spontaneously hypertensive rat plasma
Radioimmunoassay
1.05 ± 0.04 min
PaperSynthetic human adrenomedullin and adrenomedullin 15-52 have potent short-lived vasodilator activity in the hindlimb vascular bed of the cat
RECORD: Rec_0295367 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Rattus norvegicus [Animal]
Calcitonin family
9606; 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
14-19
Bio-Activity Profile
Hypotensive Vasodilatory
Spontaneously hypertensive rat plasma (slow component)
Radioimmunoassay
18.1 ± 1.4 min
PaperSynthetic human adrenomedullin and adrenomedullin 15-52 have potent short-lived vasodilator activity in the hindlimb vascular bed of the cat
RECORD: Rec_0298139 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0312478 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Rattus norvegicus [Animal]
Calcitonin family
9606; 10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
14-19
Bio-Activity Profile
Hypotensive Vasodilatory
Rat after intravenous administration (distribution phase)
Competitive radioimmunoassay
2 min
PaperBiodistribution, plasma kinetics and quantification of single-pass pulmonary clearance of adrenomedullin
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