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MYP_056928
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Basic Information
Cter B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C141H227N35O42S6
Standard
Sequence
GVPCAESCVWIPCTVTALLGCSCKDKVCYLN
Physicochemical Analysis
3276.91 Da
6.03
-0.30
-0.60
-0.0096
0.77
0.25
0.27
37.21
94.19
0.0645
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1205.41
-11.46
47.0
48.0
100.0
224.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0284631 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal
Human lung carcinoma A549
0.7 μM
IC50
PaperPubMed PMID 2341998 | PubMed PMID 8286697 | PubMed PMID 6000000 | Gilding et al., 2016 PMID2341998;8286697;6000000;23419988;28669;76000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0382493 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal
Candida albicans
160 μM
MIC
PaperPubMed PMID 2341998 | PubMed PMID 8286697 | PubMed PMID 6000000 | Gilding et al., 2016 PMID2341998;8286697;6000000;23419988;28669;76000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0393188 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal
Human lung carcinoma A549/paclitaxel
2.53 μM
IC50
PaperPubMed PMID 2341998 | PubMed PMID 8286697 | PubMed PMID 6000000 | Gilding et al., 2016 PMID2341998;8286697;6000000;23419988;28669;76000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0400694 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Anti-Gram-negative
Pseudomonas aeruginosa
1.25 μM
MIC
PaperPubMed PMID 2341998 | PubMed PMID 8286697 | PubMed PMID 6000000 | Gilding et al., 2016 PMID2341998;8286697;6000000;23419988;28669;76000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2341998/
RECORD: Rec_0419938 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Candida albicans
160 μM
MIC
PMID28669767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
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