Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length286 amino acids

Chemical FormulaC1413H2286N362O400S11

DescriptionStandard

        MGDICQVLTSSVSSKLQPYVETLPLKERLDSVAGIDYSLVAPPRATADSLDMQLKGEFYNVASPSPPPFMPPPMAIPSLHDRMIYLAISDYLFNTAALVYQQAGAFGLTLRDDMIPKESKSRLTTKFLGKALPQVAKMFPNMNVQLTLSVSSPPHLTTRPTGIALTAAVDLQAFAILPNSSLASLFLLGLKLNTSAKIGTKADKLVGELTLGRLILELKHSNIGSFPVELLQALMDYVLSAVVLPKVNEKLQRGLPLPMPRKVQLYDLVLQPHQDFLLLGANVQHG
    

Molecular Weight31098.17 Da

Isoelectric Point (pI)8.85

Net Charge (pH 7.0)2.94

Net Charge (pH 7.4) 2.40

Charge Density (pH 7.0) 0.0103

GRAVY Index0.18

Hydrophobic Moment 0.67

Boman Index0.15

Instability Index40.43

Aliphatic Index 110.49

Aromaticity 0.0629

Extinction Coeff. Reduced 11920.00

Extinction Coeff. Oxidized 11920.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0390915 VERIFIED: NO

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyBPI

Tax ID9986

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence