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MYP_056799
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Basic Information
Magainin-M1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
23 amino acids
C113H179N29O28S
Standard
Sequence
GIGKFLHSAGKFGKAFIGEIMKS
Physicochemical Analysis
2423.87 Da
10.00
2.85
2.59
0.1237
0.23
0.64
0.24
-0.10
76.52
0.1304
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
914.04
-6.74
32.0
33.0
85.0
171.0
4.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0192813 VERIFIED: YES
Provenance & Taxonomy
Xenopus muelleri [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
25 μM
MIC
PMID21664395 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21664395/
RECORD: Rec_0232948 VERIFIED: YES
Provenance & Taxonomy
Xenopus borealis [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0243478 VERIFIED: YES
Provenance & Taxonomy
Xenopus muelleri [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human erythrocytes
180 μM
Hemolysis
PMID21664395 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21664395/
RECORD: Rec_0251026 VERIFIED: YES
Provenance & Taxonomy
Xenopus muelleri [Animal]
Magainin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic
Candida albicans
50 μM
MIC
RECORD: Rec_0284904 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Toxic Hemolytic Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
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