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MYP_056735
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C131H206N34O42S6
Standard
Sequence
GIPCAESCVWIPCTVTALLGCSCSNNVCYN
Physicochemical Analysis
3121.63 Da
4.05
-1.30
-1.59
-0.0432
0.79
0.22
0.32
33.57
87.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1193.38
-14.59
46.0
47.0
92.0
213.0
5.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0149535 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
human type A red blood cells
PaperPubMed PMID: 10600388 PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0272870 VERIFIED: YES
Provenance & Taxonomy
Austalian native violet [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
-
PaperCycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae.
RECORD: Rec_0345799 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
PaperPubMed PMID: 10600388 PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0360811 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0381587 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16441062 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16441062/
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