Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length488 amino acids

Chemical FormulaC2421H3849N645O685S20

DescriptionStandard

        MARGPCNAPRWASLLVLVAVGTAVAAAINPGVVVRISQKGLDYATQQGTAALQKELERIKIPDYSGSFKIKHLGKGHYSFYSMDIREFQLPSSQIRMVPNVGLKFSISNANIKISGKWKARKSFLKTSGRFDLSVEGMSISADLKLGGNLTSGKPTVTCSSCSSHISSVHVHISNSKVGWLIQLFHKKIESALRNKLNSQVCQEVTSSVSSKLQPYFQTLPVMTKIDAVAGINYGLVAPPMTTAETLDVQMKGEFYRLNHHNPPPFAPPVMEFPAAHDRMVYLALSDYFFNTAGLVYQEAGVLKMILTDDMIPKESKFRLTTKFFGSFLPEVAKMFPNMKIQIHISASAPPQLSVQPTGLSFFPAVDVQAFAVLANSSLASLFLIGMSTSGSLEVSARSDRLVGELKVDRLLLELKHSNIGPFPVELLQDIMNYIVPTLVLPRVNEKLQKGFPLPMPARVQLYNTVLQSHQVSPRVSFPQISPNNSDQ
    

Molecular Weight53592.67 Da

Isoelectric Point (pI)9.58

Net Charge (pH 7.0)16.53

Net Charge (pH 7.4) 15.54

Charge Density (pH 7.0) 0.0339

GRAVY Index0.02

Hydrophobic Moment 0.70

Boman Index0.10

Instability Index42.55

Aliphatic Index 93.87

Aromaticity 0.0820

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0337809 VERIFIED: NO

Provenance & Taxonomy

OrganismAotus nancymaae [Animal]

FamilyBPI/LBP

Tax ID37293

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria