Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length460 amino acids

Chemical FormulaC2257H3613N579O657S20

DescriptionStandard

        MFLCCWLGLVALIPTTLSTNPGVKVRLTEKGIEYGRQLGMAVIQQKLGSIKIPDFSGTEKVSPIGKVQYSLSNMHIVNVGLPKSSVDLVPGTGVTLSIGDAFISLNGNWRVKYLRIIKDSGSFDLNVNGLSIATTISIKSDETGRPAVSSDSCSATVGSAKVKFHGGASWLYNLFTTFIDKALRNAMQKQICPLVADAVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSSIDLSLKGEFYNIGKHQEPPFSPAAFNLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSITDDMIPKSSPIRLNTKTFGAFIPQIAKQFPGLMMKLLVKTEKPPTLTFEPNNATVQATATVTAFAIQPNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLDKSYVGDFQVRSAFLYNNIQLAKGYPLPTIGKMKLMNTQLDVLKVRDTDNMFNKFV
    

Molecular Weight50012.61 Da

Isoelectric Point (pI)9.34

Net Charge (pH 7.0)11.73

Net Charge (pH 7.4) 11.20

Charge Density (pH 7.0) 0.0255

GRAVY Index0.11

Hydrophobic Moment 0.72

Boman Index0.14

Instability Index32.79

Aliphatic Index 96.85

Aromaticity 0.0826

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0145824 VERIFIED: NO

Provenance & Taxonomy

OrganismNeolamprologus brichardi [Bacterium]

FamilyBPI

Tax ID32507

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence