Peptide Database

Peptide Name3F1B35

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-Influenza virus

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza

Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross

Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC175H280N54O61

DescriptionStandard

        ELNKAKSDLEESKEWIRRSNQKLDSIGNWHQSSTT
    

Molecular Weight4116.42 Da

Isoelectric Point (pI)6.87

Net Charge (pH 7.0)-0.07

Net Charge (pH 7.4) -0.30

Charge Density (pH 7.0) -0.0020

GRAVY Index-1.50

Hydrophobic Moment 0.66

Boman Index-0.37

Instability Index76.28

Aliphatic Index 58.57

Aromaticity 0.0571

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1941.95

LogP -24.50

H-bond Donors 68.0

H-bond Acceptors 62.0

Rotatable Bonds 145.0

Heavy Atoms 290.0

Ring Count 5.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0309038 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-Influenza virus Entry inhibition

TargetHuman parainfluenza virus type 3 (HPIV-3) | HEp-2 cells

Activity0.583 μM

MethodEC50

Half-LifeMammalian: 1 h; Yeast: 30 min; E. coli: >10 h

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91. | DOI:10.1073/pnas.93.5.2186 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

RECORD: Rec_0331673 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyRespiratory syncytial virus fusion-inhibitory peptide

Tax ID32630.0

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Bio-Activity Profile

Function

Antiviral Anti-Influenza Anti-RSV Anti-HPIV3 Fusion inhibitor

TargetHuman parainfluenza virus 3

RECORD: Rec_0391897 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHIV gp41 fusion inhibitor

Tax ID32630.0

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Bio-Activity Profile

Function

Antiviral Anti-HIV Anti-Influenza Anti-HPIV3

TargetHuman parainfluenza virus 3

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