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MYP_056540
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Basic Information
3F1B35
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection
Standard
35 amino acids
C175H280N54O61
Standard
Sequence
ELNKAKSDLEESKEWIRRSNQKLDSIGNWHQSSTT
Physicochemical Analysis
4116.42 Da
6.87
-0.07
-0.30
-0.0020
-1.50
0.66
-0.37
76.28
58.57
0.0571
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1941.95
-24.50
68.0
62.0
145.0
290.0
5.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071788 VERIFIED: YES
Provenance & Taxonomy
Human parainfluenza virus 3 [Virus]
Virus-derived peptide
11216;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor
Human parainfluenza virus type 3 (Virus entry); Vero
2.2 μM
Plaque assay
PaperPeptides corresponding to the heptad repeat sequence of human parainfluenza virus fusion protein are potent inhibitors of virus infection. | Yao Q, Compans RW. | Virology. 1996 | PMID:8806544 PMID8806544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8806544/
RECORD: Rec_0077326 VERIFIED: YES
Provenance & Taxonomy
Human parainfluenza virus 3 [Virus]
Virus-derived peptide
11216;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Human parainfluenza virus type 3 (Hemagglutinin-Neuraminidase)
Cell-fusion assay
PaperMethods and compositions for inhibition of membrane fusion-associated events | Shawn O'Lin, Dennis Michael, Stephen Robert | Trimeris, Inc., Durham NC (US) | Patent:US6951717 Evidence URLhttps://patents.google.com/patent/US6951717/en PatentUS6951717
RECORD: Rec_0120711 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Evidence URLhttps://patents.google.com/patent/US6228983B1/en PatentUS 6228983 B1
RECORD: Rec_0216465 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 68.6%, E 0.0%, T 11.4%, C 20.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0243877 VERIFIED: YES
Provenance & Taxonomy
Human parainfluenza virus 3 [Virus]
Virus-derived peptide
11216;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor Cytoprotective
Human parainfluenza virus type 3 (Fusion); HEp2
2.4 μM
EC50
PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
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