Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length458 amino acids

Chemical FormulaC2314H3617N611O651S11

DescriptionStandard

        TNPGFVARITQAGLDYAHQQGIAVLEKELVQLKLPDISGDYRVRHVGKVHYELSSLDLRSFHLPYSRISLVPNVGLQVSISNAFAEVDGNWRVKIYFVRDHGSFDLKVENIYIKINLKLGSDTSGKPTIDTSDCSTRISQVRVHFSGKFGWLYNIFHSVIESRFRKILEGKVCENVVSSVRSEPQPYLQTLPVTARIDAVAGIDYSLVAPPTATAQSLDVDLKGEFFSLAHRSAVPFSPLALSFPPDHDRMVYFGASSYFFNTAGFAYHAAGALVFEITDSMIPKDIEFHLKTSTFSAFIPQLETMYPDMPMKLRLSTSSAPFLNIGPGGVSLKPVVDIQAYAIFPNSSLAPLFLLSLVSSGNVSAVIDMKSSHIVGNLTVGRMKLSLKHSDVGTFQVRMLQSIMNILASSILLPRLNARLDQGFPLPLPDRIQLFNVLVQFHQNFLLLGADVRYQPR
    

Molecular Weight50764.89 Da

Isoelectric Point (pI)8.84

Net Charge (pH 7.0)4.63

Net Charge (pH 7.4) 3.61

Charge Density (pH 7.0) 0.0101

GRAVY Index0.10

Hydrophobic Moment 0.68

Boman Index0.12

Instability Index35.11

Aliphatic Index 100.85

Aromaticity 0.1004

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0111138 VERIFIED: NO

Provenance & Taxonomy

OrganismNipponia nippon [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria