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MYP_056402
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Basic Information
Citropin-1.3
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
16 amino acids
C77H132N18O20
Standard
Sequence
GLFDIIKKVASVIGGL
Physicochemical Analysis
1629.98 Da
8.59
0.76
0.55
0.0474
1.30
0.65
0.47
14.19
164.38
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
609.39
-2.91
21.0
21.0
56.0
115.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016770 VERIFIED: YES
Provenance & Taxonomy
Litoria citropa [Animal]
Citropin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer nNOS inhibitor
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0024725 VERIFIED: YES
Provenance & Taxonomy
Litoria citropa [Animal]
Citropin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
15.36 μM
MIC
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0024953 VERIFIED: YES
Provenance & Taxonomy
Litoria citropa [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
25 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID10504394;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10504394/
RECORD: Rec_0025150 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0089238 VERIFIED: YES
Provenance & Taxonomy
Litoria citropa [Animal]
Citropin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
PMID10504394;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10504394/
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