Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length548 amino acids

Chemical FormulaC2711H4312N726O768S22

DescriptionStandard

        MLGDHQLLYRSLAPLQGLKALAALEDEDMARHPDNALRWATLLVLAILGTAAVVTTTNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPTFSGSFKVKHLGKGHYSFYSMVIRGFQLPSSQIKLVPNKGLDLSIRNANIKISGKWKARKNFIKTSGNFDLSVESISISAGLNMSFDPTSGHLTIICSSCNNYIDSVRVHISGGRLGWLIQLFHKKIESAIRKTMNNKICQVVSSSVSSRLQSYLKTLPVTYKIDRIAGISYSLVAPPTATADNLDGHLKGEFFSLAHPRSPPFTPPAMALPPDHDHMVYLGISDYFFNTAGLVYQEAGALNMTITDDMIPKKSKFRLTTDFLGTLIPQVAEMFPNMTVQFNVWASSPPHLTMRPAGLIFTPTLDTQAFAVLPNSSLAPLFVLGLSTNLSMEVSARPDRLVGQLSLDKLLLELKHSDVGSFSVAVLQSIMNYVVPTAVLPKVNERLQEGFPLPMPKNVQLFNLVLQTHQVGPKVSFHQMCASRVPSTLYPFSTLQGGWAVNEPGRKSKAQESCTAKH
    

Molecular Weight60069.07 Da

Isoelectric Point (pI)9.47

Net Charge (pH 7.0)16.86

Net Charge (pH 7.4) 15.63

Charge Density (pH 7.0) 0.0308

GRAVY Index0.02

Hydrophobic Moment 0.75

Boman Index0.11

Instability Index38.70

Aliphatic Index 96.08

Aromaticity 0.0785

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47245.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0076706 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria