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MYP_056267
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Basic Information
Brevinin-1VLc
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C127H208N28O27S2
Standard
Sequence
FLPVIASVAAKVLPKVFCFITKKC
Physicochemical Analysis
2623.31 Da
9.70
3.74
3.50
0.1557
1.33
0.56
0.38
26.58
125.83
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
859.58
-2.09
31.0
33.0
83.0
184.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076517 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
7.0 μM
HC50
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 150 (2009) 150-154. Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
RECORD: Rec_0081014 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
50.0 μM
MIC
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 150 (2009) 150-154. Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
RECORD: Rec_0107520 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anticancer Anti-Gram-negative
Escherichia coli
50 μM
MIC
RECORD: Rec_0134212 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
1500 μM
MIC
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
RECORD: Rec_0137904 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
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