Peptide Database

Peptide NameCholecystokinin

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length95 amino acids

Chemical FormulaC462H738N150O142S3

DescriptionStandard

        QPVPPAEPAGSGLQRAEEAPRRQLRAVQRTDGESRAHLGALLARYIQQARKAPSGRMSIIKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS
    

Molecular Weight10761.92 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)2.95

Net Charge (pH 7.4) 2.63

Charge Density (pH 7.0) 0.0311

GRAVY Index-0.99

Hydrophobic Moment 0.84

Boman Index-0.25

Instability Index81.67

Aliphatic Index 62.84

Aromaticity 0.0632

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4756.69

LogP -54.54

H-bond Donors 166.0

H-bond Acceptors 150.0

Rotatable Bonds 355.0

Heavy Atoms 757.0

Ring Count 17.0

Amide Bonds 103.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0217738 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyGastrin/cholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsTyr77 Sulfotyrosine; Phe83 Amidation; Tyr91 Sulfotyrosine; Tyr93 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide

RECORD: Rec_0266452 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyCholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods77:Sulfotyrosine; 83:Phenylalanine amide; 91:Sulfotyrosine; 93:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0406379 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/