Peptide Database

Peptide NameI-7

Function Ontology

Anticancer

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC112H192N42O20

DescriptionStandard

        LVRRFRRFFRRLRRSVLL
    

Molecular Weight2446.99 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.76

Net Charge (pH 7.4) 7.56

Charge Density (pH 7.0) 0.4311

GRAVY Index-0.27

Hydrophobic Moment 1.19

Boman Index-0.58

Instability Index171.84

Aliphatic Index 118.89

Aromaticity 0.1667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1073.45

LogP -7.04

H-bond Donors 44.0

H-bond Acceptors 28.0

Rotatable Bonds 84.0

Heavy Atoms 174.0

Ring Count 3.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0248082 VERIFIED: YES

Provenance & Taxonomy

Organismcationic host defense peptides [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetK562

Activity6.9±0.2 μM

MethodIC50

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

RECORD: Rec_0329216 VERIFIED: YES