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MYP_056167
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Basic Information
C14-HBD-1 (16-36) [C27,35Del], MPhd-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
19 amino acids
C94H157N27O24S2
Standard
Sequence
ACPIFTKIQGTYRGKAKCK
Physicochemical Analysis
2113.55 Da
9.90
4.77
4.55
0.2511
-0.44
0.47
-0.12
15.96
51.58
0.1053
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
848.09
-8.12
32.0
31.0
71.0
147.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037921 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
- at NA , Rat erythrocytes
7.5 μM
Hemolysis
PMID24086767;16860904;18809937;23980689;29682907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086767/
RECORD: Rec_0078914 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus NCTC 8530
12 μg/mL
MBC
PMID24086767;16860904;18809937;23980689;29682907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086767/
RECORD: Rec_0112405 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus NCTC 8530
PMID24086767;16860904;18809937;23980689;29682907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086767/
RECORD: Rec_0160699 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli MG1655
12 μg/mL
MBC
PMID24086767;16860904;18809937;23980689;29682907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086767/
RECORD: Rec_0172251 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-18
Bio-Activity Profile
Antimicrobial
Escherichia coli (LC 19 uM). LC=lethal concentration. Antimicrobial robustness: NaCl-insensitive:Escherichia coli (150 mM); MgCl2-sensitive:Escherichia coli (2.5 mM)
PaperHuman-beta-defensins-1-3 and analogs do not require proton motive force for antibacterial activity against Escherichia coli.
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