Peptide Database

Peptide NameVedolizumab

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Integrin inhibitor

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC299H454N82O91S2

DescriptionStandard

        QVQLVQSGAEVKKPGASVKVSCKGSGYTFTSYWMHWVRQAPGQRLEWIGEIDPSESNTNY
    

Molecular Weight6717.43 Da

Isoelectric Point (pI)8.11

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0140

GRAVY Index-0.61

Hydrophobic Moment 0.53

Boman Index-0.01

Instability Index34.13

Aliphatic Index 60.00

Aromaticity 0.1167

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 20970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2808.90

LogP -30.46

H-bond Donors 98.0

H-bond Acceptors 95.0

Rotatable Bonds 217.0

Heavy Atoms 474.0

Ring Count 14.0

Amide Bonds 66.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0280442 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Anti-inflammatory Integrin inhibitor

Half-Life336 to 362 h.

PaperPubMed-linked source references: PMID:28204866; PMID:27539137; PMID:25484055; PMID:24846335; PMID:24284914; PMID:23727858; PMID:23254906; PMID:21051951; PMID:28296827 PMID28204866;27539137;25484055;24846335;24284914;23727858;23254906;21051951;28296827 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28204866/ PatentUS2012151248