Peptide Database

Peptide NameInsulin aspart

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic

Standard StatusStandard

Sequence Length51 amino acids

Chemical FormulaC256H385N65O78S6

DescriptionStandard

        GIVEQCCTSICSLYQLENYCNFVNQHLCGSHLVEALYLVCGERGFFYTDKT
    

Molecular Weight5813.57 Da

Isoelectric Point (pI)4.92

Net Charge (pH 7.0)-3.12

Net Charge (pH 7.4) -3.52

Charge Density (pH 7.0) -0.0611

GRAVY Index0.18

Hydrophobic Moment 0.44

Boman Index0.16

Instability Index10.66

Aliphatic Index 85.88

Aromaticity 0.1373

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2310.94

LogP -21.92

H-bond Donors 85.0

H-bond Acceptors 83.0

Rotatable Bonds 188.0

Heavy Atoms 405.0

Ring Count 9.0

Amide Bonds 56.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0266495 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]

FamilyInsulin

Tax ID9606;4932

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideA6-A11, A7-B7, A20-B19

Other ModsProB28→Asp substitution relative to human insulin

Bio-Activity Profile

Function

Antidiabetic Hypoglycemic Insulin analog

Half-Life81 min. SC injection