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MYP_056033
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Basic Information
Brevinin-2PRb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
37 amino acids
C173H291N49O48S3
Standard
Sequence
GLMSLFRGVLKTAGKHIFKNVGGSLLDQAKCKITGEC
Physicochemical Analysis
3921.66 Da
9.59
3.83
3.53
0.1034
0.16
0.67
0.10
28.82
94.86
0.0541
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1573.30
-15.49
57.0
56.0
138.0
273.0
3.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294112 VERIFIED: YES
Provenance & Taxonomy
Rana pirica [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
25.0 μM
MIC
PaperJ.M. Conlon et al. / Regulatory Peptides 118 (2004) 135-141. A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica
RECORD: Rec_0334986 VERIFIED: YES
Provenance & Taxonomy
Rana pirica [Animal]
Brevinin
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PMID15003829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15003829/
RECORD: Rec_0338524 VERIFIED: YES
Provenance & Taxonomy
Rana pirica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
31-37
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
25 μM
MIC
PaperA family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica.
RECORD: Rec_0349870 VERIFIED: YES
Provenance & Taxonomy
Rana pirica [Animal]
Brevinin
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterobacter cloacae
6 μM
MIC
PMID15003829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15003829/
RECORD: Rec_0354317 VERIFIED: YES
Provenance & Taxonomy
Rana pirica [Animal]
Brevinin
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
6 μM
MIC
PMID15003829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15003829/
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